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Perfusion ImagingForum -
related threadsInfoSheet: - Sequences - 
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(PWI - Perfusion Weighted Imaging) Perfusion MRI techniques (e.g. PRESTO - Principles of Echo Shifting using a Train of Observations) are sensitive to microscopic levels of blood flow. Contrast enhanced relative cerebral blood volume (rCBV) is the most used perfusion imaging. Both, the ready availability and the T2* susceptibility effects of gadolinium, rather than the T1 shortening effects make gadolinium a suitable agent for use in perfusion imaging. Susceptibility here refers to the loss of MR signal, most marked on T2* (gradient echo)-weighted and T2 (spin echo)-weighted sequences, caused by the magnetic field-distorting effects of paramagnetic substances.
T2* perfusion uses dynamic sequences based on multi or single shot techniques. The T2* (T2) MRI signal drop within or across a brain region is caused by spin dephasing during the rapid passage of contrast agent through the capillary bed. The signal decrease is used to compute the relative perfusion to that region. The bolus through the tissue is only a few seconds, high temporal resolution imaging is required to obtain sequential images during the wash in and wash out of the contrast material and therefore, resolve the first pass of the tracer. Due to the high temporal resolution, processing and calculation of hemodynamic maps are available (including mean transit time (MTT), time to peak (TTP), time of arrival (T0), negative integral (N1) and index.
An important neuroradiological indication for MRI is the evaluation of incipient or acute stroke via perfusion and diffusion imaging. Diffusion imaging can demonstrate the central effect of a stroke on the brain, whereas perfusion imaging visualizes the larger 'second ring' delineating blood flow and blood volume. Qualitative and in some instances quantitative (e.g. quantitative imaging of perfusion using a single subtraction) maps of regional organ perfusion can thus be obtained.
Echo planar and potentially echo volume techniques together with appropriate computing power offer real time images of dynamic variations in water characteristics reflecting perfusion, diffusion, oxygenation (see also Oxygen Mapping) and flow.
Another type of perfusion MR imaging allows the evaluation of myocardial ischemia during pharmacologic stress. After e.g., adenosine infusion, multiple short axis views (see cardiac axes) of the heart are obtained during the administration of gadolinium contrast. Ischemic areas show up as areas of delayed and diminished enhancement. The MRI stress perfusion has been shown to be more accurate than nuclear SPECT exams. Myocardial late enhancement and stress perfusion imaging can also be performed during the same cardiac MRI examination.
 
Images, Movies, Sliders:
 Normal Lung Gd Perfusion MRI  Open this link in a new window
      

Courtesy of  Robert R. Edelman

 Left Circumflex Ischemia First-pass Contrast Enhancement  Open this link in a new window
 
Radiology-tip.comradPerfusion Scintigraphy
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Medical-Ultrasound-Imaging.comBolus Injection
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• Related Searches:
    • Echo Planar Imaging
    • Brain MRI
    • Gd Labeled Albumin
    • Blood Oxygenation Level Dependent Contrast
    • Perfusion Agents
 
Further Reading:
  Basics:
CHAPTER 55: Ischemia
2003
EVALUATION OF HUMAN STROKE BY MR IMAGING
2000
  News & More:
Non-invasive diagnostic procedures for suspected CHD: Search reveals informative evidence
Wednesday, 8 July 2020   by medicalxpress.co    
Implementation of Dual-Source RF Excitation in 3 T MR-Scanners Allows for Nearly Identical ADC Values Compared to 1.5 T MR Scanners in the Abdomen
Wednesday, 29 February 2012   by www.plosone.org    
Motion-compensation of Cardiac Perfusion MRI using a Statistical Texture Ensemble(.pdf)
June 2003   by www.imm.dtu.dk    
Turbo-FLASH Based Arterial Spin Labeled Perfusion MRI at 7 T
Thursday, 20 June 2013   by www.plosone.org    
Measuring Cerebral Blood Flow Using Magnetic Resonance Imaging Techniques
1999   by www.stanford.edu    
Vascular Filters of Functional MRI: Spatial Localization Using BOLD and CBV Contrast
MRI Resources 
MRI Centers - Stent - Image Quality - Contrast Agents - Hospitals - Pediatric and Fetal MRI
 
Posterior
 
A tomographic imaging direction, backwards relative to a short axis of the human body from the back to the front.
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• View the NEWS results for 'Posterior' (1).Open this link in a new window.
 
Further Reading:
  Basics:
Changes of the Posterior Meniscal Horn Height During Loading: An In Vivo Magnetic Resonance Imaging Study
Thursday, 10 January 2008   by www.orthosupersite.com    
MRI Resources 
MRI Technician and Technologist Jobs - Process Analysis - Libraries - Musculoskeletal and Joint MRI - - Implant and Prosthesis
 
Signa Infinity 1.0Tâ„¢InfoSheet: - Devices -
Intro, 
Types of Magnets, 
Overview, 
etc.MRI Resource Directory:
 - Devices -
 
www.gehealthcare.com/usen/mr/index.html From GE Healthcare;
the Signa Infinity Magnetic Resonance system is a short bore, high performance, whole-body imaging system operating at 1.0 Tesla. The system can image in any orthogonal or oblique plane (including single and double axis oblique), using a wide variety of pulse sequences.
Device Information and Specification
CLINICAL APPLICATION
Whole body
CONFIGURATION
Short bore
Head and body coil standard; all other coils optional; open architecture makes system compatible with a wide selection of coils
SYNCHRONIZATION
ECG/peripheral, respiratory gating
PULSE SEQUENCES
Standard: SE, IR, 2D/3D GRE and SPGR, Angiography;; 2D/3D TOF, 2D/3D Phase Contrast;; 2D/3D FSE, 2D/3D FGRE and FSPGR, SSFP, FLAIR, optional: EPI, 2D/3D Fiesta, FGRET, Spiral
IMAGING MODES
Localizer, single slice, multislice, volume, fast, POMP, multi slab, cine
TR
4.4 msec to 12000 msec in increments of 1 msec
TE
1.0 to 2000 msec; increments of 1 msec
SINGLE/MULTI SLICE
Simultaneous scan and reconstruction;; up to 100 images/second with Reflex 100
1 cm to 48 cm continuous
2D 0.7 mm to 20 mm; 3D 0.1 mm to 5 mm
1280 x 1024
MEASURING MATRIX
128x512 steps 32 phase encode
PIXEL INTENSITY
256 gray levels
0.08 mm; 0.02 mm optional
MAGNET WEIGHT
3613 kg
H*W*D
172 x 208 x 216 cm
POWER REQUIREMENTS
480 or 380/415 V
COOLING SYSTEM TYPE
Closed-loop water-cooled gradient
Less than 0.03 L/hr liquid helium
STRENGTH
SmartSpeed 23 mT/m, HiSpeed Plus 33 mT/m
5-GAUSS FRINGE FIELD
4.0 m x 2.8 m axial x radial
Active
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Hospitals - Crystallography - Software - Most Wanted - - MRI Technician and Technologist Career
 
Fast Imaging with Steady State PrecessionInfoSheet: - Sequences - 
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Overview, 
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etc.
 
(FISP) A fast imaging sequence, which attempts to combine the signals observed separately in the FADE sequence, generally sensitive about magnetic susceptibility artifacts and imperfections in the gradient waveforms. Confusingly now often used to refer to a refocused FLASH type sequence.
This sequence is very similar to FLASH, except that the spoiler pulse is eliminated. As a result, any transverse magnetization still present at the time of the next RF pulse is incorporated into the steady state. FISP uses a RF pulse that alternates in sign. Because there is still some remaining transverse magnetization at the time of the RF pulse, a RF pulse of a degree flips the spins less than a degree from the longitudinal axis. With small flip angles, very little longitudinal magnetization is lost and the image contrast becomes almost independent of T1. Using a very short TE (with TR 20-50 ms, flip angle 30-45°) eliminates T2* effects, so that the images become proton density weighted. As the flip angle is increased, the contrast becomes increasingly dependent on T1 and T2*. It is in the domain of large flip angles and short TR that FISP exhibits vastly different contrast to FLASH type sequences. Used for T1 orthopedic imaging, 3D MPR, cardiography and angiography.
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Further Reading:
  Basics:
MRI techniques improve pulmonary embolism detection
Monday, 19 March 2012   by medicalxpress.com    
MRI Resources 
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Gradient Recalled Acquisition in Steady StateInfoSheet: - Sequences - 
Intro, 
Overview, 
Types of, 
etc.
 
(GRASS) This sequence is very similar to FLASH, except that the spoiler pulse is eliminated. As a result, any transverse magnetization still present at the time of the next RF pulse is incorporated into the steady state. GRASS uses a RF pulse that alternates in sign. Because there is still some remaining transverse magnetization at the time of the RF pulse, a RF pulse of a degree flips the spins less than a degree from the longitudinal axis. With small flip angles, very little longitudinal magnetization is lost and the image contrast becomes almost independent of T1. Using a very short TE eliminates T2* effects, so that the images become proton density weighted. As the flip angle is increased, the contrast becomes increasingly dependent on T1 and T2*. It is in the domain of large flip angles and short TR that GRASS exhibits vastly different contrast to FLASH type sequences.
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MRI Resources 
Process Analysis - MRI Technician and Technologist Schools - Breast MRI - Libraries - Fluorescence - Contrast Agents
 
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